Napoli give Hirving Lozano a new False 9 role in the trident attack against Parma, who make radical changes to their front three.
It kicks off at the Stadio Tardini at 18.30 UK time (17.30 GMT).
The Partenopei are without suspended Arkadiusz Milik, while Fernando Llorente is injured and Dries Mertens nursing a knock.
In order not to risk the Belgian, Gennaro Gattuso is instead experimenting a new False 9 role for Chucky Lozano, who has otherwise struggled to make an impact on the wing.
He’ll be flanked by Lorenzo Insigne and Matteo Politano, the latter scoring the last-gasp winner against Udinese at the weekend.
Giovanni Di Lorenzo returns from suspension and Alex Meret goes in goal for David Ospina, while Allan gets an increasingly rare start.
Parma are on an awful run of form with one point from their last seven games, plus an injury crisis ruling out Andreas Cornelius, Riccardo Gagliolo and Matteo Scozzarella.
Matteo Darmian and Alberto Grassi return from suspension, with Bruno Alves and Juraj Kucka carrying knocks.
With Roberto Inglese not yet fully fit, coach Roberto D’Aversa has surprisingly rested Dejan Kulusevski and Gervinho too, starting Luca Siligardi, Gianluca Caprari and Inter-owned Yann Karamoh.
Parma: Sepe; Darmian, Dermaku, Bruno Alves, Pezzella; Grassi, Brugman, Kurtic; Siligardi, Caprari, Karamoh
Napoli: Meret; Di Lorenzo, Maksimovic, Koulibaly, Mario Rui; Fabian Ruiz, Demme, Allan; Politano, Lozano, Insigne
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