Inter need a victory to recapture second place and put pressure on Juventus, so Christian Eriksen supports Romelu Lukaku and Lautaro Martinez, while Goran Pandev’s Genoa are fighting to avoid relegation.
It kicks off at Marassi at 18.30 UK time (17.30 GMT).
Atalanta were held 1-1 by Milan last night, which means Inter can leapfrog them to take back second place with a victory here this evening, as well as put pressure on leaders Juventus.
However, Genoa have even more motivation, as they are still hovering just above the relegation zone, even after their hard-fought 2-1 Derby della Lanterna win over Sampdoria.
Nicolò Barella sits out a ban, with injured Matias Vecino, Stefano Sensi and Stefan de Vrij, so Borja Valero, Andrea Ranocchia and Diego Godin start.
Eriksen is given the nod in the trequartista role behind Lautaro Martinez and Romelu Lukaku, sending Alexis Sanchez to the bench.
Genoa are without the derby hero Lukas Lerager, who is suspended after scoring the winning goal against Samp, while Stefano Sturaro and Ivan Radovanovic also miss out.
Pandev won the Treble with Inter in 2010, but he’s still going strong for Genoa and is on the bench this evening, as Andrea Pinamonti partners Andrea Favilli.
Valon Behrami and Francesco Cassata aren’t fully fit either, so 18-year-old Nicolò Rovella gets his first Serie A start.
Curiously, Ravella’s only previous Serie A appearance was as a substitute in the 4-0 defeat to Inter back in December.
Genoa: Perin; Goldaniga, Romero, C Zapata; Ankersen, Rovella, Behrami, Jagiello, Criscito; Favilli, Pinamonti
Genoa bench: Ichazo, Marchetti, Barreca, Biraschi, Eriksson, Ghiglione, Pandev, Schone, Destro, Bianchi, Cassata, Masiello
Inter: Handanovic; Skriniar, Ranocchia, Godin; Moses, Brozovic, Gagliardini, Biraghi; Eriksen; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Berni, De Vrij, Alexis Sanchez, Young, Borja Valero, Esposito, Pirola, Agoume, D’Ambrosio, Candreva, Bastoni
Watch Serie A live in the UK on Premier Sports for just £9.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://www.premiersports.com/subscribenow